C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/64 (2006.01) A61K 38/10 (2006.01) A61K 38/48 (2006.01) A61K 38/57 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07K 14/81 (2006.01)
Patent
CA 2747220
Based on the discovery that a soluble polypeptide including a nonphosphorylatable form of the MT1-MMP cytoplasmic domain is capable of inhibiting MT1-MMP in a dominant negative manner, the present invention provides compositions including MT1-MMP inhibitors such as peptide inhibitors, and methods for treating diseases associated with MT1-MMP activity. Such diseases include cancer, arthritis, and heart disease, and vascular disease.
En se fondant sur la découverte qu'un polypeptide soluble comprenant une forme non apte à être phosphorylée du domaine cytoplasmique de MTl-MMP est apte à inhiber la MTl-MMP d'une manière négative dominante, la présente invention porte sur des compositions comprenant des inhibiteurs de la MTl-MMP tels que des inhibiteurs peptidiques et sur des procédés pour le traitement de maladies associées à l'activité de la MTl-MMP. De telles maladies comprennent un cancer, l'arthrite et une maladie cardiaque et une maladie vasculaire.
Beliveau Richard
Gingras Denis
Nyalendo Carine
Angiochem Inc.
Goudreau Gage Dubuc
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