Membrane with tissue-guiding surface corrugations

A - Human Necessities – 61 – F

Patent

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Details

A61F 2/28 (2006.01) A61B 17/80 (2006.01) A61B 17/68 (2006.01) A61F 2/30 (2006.01) A61F 2/46 (2006.01)

Patent

CA 2327789

A resorbing, flexible implant in the form of a continuous macro-porous sheet (42) is disclosed. The implant is adapted to protect biological tissue defects, especially bone defects in the mammalian skeletal system, from the interposition of adjacent soft tissues during in vitro repair. The membrane (42) has pores with diameters from 20 microns to 3000 microns. This porosity is such that vasculature, and connective tissue cells derived from the adjacent soft tissues including the periosteum, can proliferate through the membrane into the bone defect. The thickness of the sheet is such that the sheet has both sufficient flexibility to allow the sheet to be shaped to conform to the configuration of a skeletal region to be repaired, and sufficient tensile strength to allow the sheet to be so shaped whitout damage to the sheet. The sheet provides enough inherent mechanical strength to withstand pressure from adjacent musculature, and does not collapse.

L'invention concerne un implant résorbable et souple présenté sous la forme d'une feuille (42) macroporeuse continue. Cet implant est conçu pour protéger les défauts des tissus biologiques, notamment les défauts osseux du squelette des mammifères, de l'interposition de tissus mous adjacents pendant une réparation in vitro. La membrane (42) présente des pores dont les diamètres varient entre 20 microns et 3000 microns. La porosité est telle que le système vasculaire et les cellules conjonctives des tissus mous adjacents, y compris le périoste, peuvent proliférer à travers la membrane et pénétrer dans le défaut osseux. L'épaisseur de la feuille est telle que la feuille est à la fois suffisamment souple pour lui permettre d'être façonnée et d'épouser la configuration d'une région squelettique à réparer, et suffisamment résistante à la traction pour lui permettre d'être ainsi façonnée sans subir de dommages. La feuille fournit une résistance mécanique suffisante pour supporter la pression de la musculature adjacente. En outre, la feuille ne s'affaisse pas.

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