C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/28 (2006.01) A61K 38/00 (2006.01) A61K 38/10 (2006.01) C40B 60/12 (2006.01) C40B 70/00 (2006.01) G01N 27/40 (2006.01) G01N 33/48 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2550854
The present invention provides a thiosulfonate-activated ionophore comprising an ionophore, a spacer group, and an alkylthiosulfonate moiety. A preferred ionophore is gramicidin A. A preferred alkylthiosulfonate is methanethiosulfonate. The present invention also provides a conjugate comprising an ionophore, a spacer group, and a recognition molecule. Further the invention related to membranes incorporating the conjugates and biosensors comprising said membranes.
La présente invention concerne un ionophore activé par thiosulfonate qui comprend un ionophore, un groupe espaceur et un groupe fonctionnel d'alkylthiosulfonate. Un ionophore préféré est la gramicidine A. Un alkylthiosulfonate préféré est le méthanethiosulfonate. La présente invention concerne aussi un conjugué comprenant un ionophore, un groupe espaceur et une molécule de reconnaissance. De plus, l'invention concerne des membranes comprenant des conjugués de l'invention et des biocapteurs comprenant ces membranes.
Genencor International Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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