Memno peptides, a process for their preparation and their use

Details Memno peptides, a process for their preparation and their use Memno peptides, a process for their preparation and their use

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61P 9/04 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2401032

The invention relates to peptide derivatives, called memno peptides, of the formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, and (A)n have the meaning herein, obtainable by cultivation of Memnoniella echinata FH2272, DSM 13195 or mutants and variants of this, a process for their preparation and the use of the compounds as pharmaceuticals, for example against cardiac insufficiency.

L'invention concerne des dérivés de peptides, appelés peptides memno, de formule (I): dans laquelle R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6?, R¿7?, R¿8?, et (A)n ont les significations selon les revendications, pouvant être obtenus par culture du Memnoniella echinata FH2272, DSM 13195 ou des mutants ou variants de celui-ci, ainsi qu'un procédé de préparation et d'utilisation des composés en tant qu'agents pharmaceutiques, par exemple contre l'insuffisance cardiaque.

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