Mengovirus as a vector for expression of foreign polypeptides

Details Mengovirus as a vector for expression of foreign polypeptides Mengovirus as a vector for expression of foreign polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 39/12 (2006.01) A61K 39/295 (2006.01) C07K 14/08 (2006.01) C07K 14/085 (2006.01) C07K 14/145 (2006.01) C07K 14/16 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2164297

This invention relates to attenuated recombinant mengoviruses expressing a heterologous amino acid sequence. The recombinant mengoviruses can express amino acid sequences comprising epitopes of various viral pathogens and are useful as live vaccines for humans and animals against these pathogens. Consequently, this invention also relates to vaccines comprising these recombinant mengoviruses or proteins thereof, cells infected with the recombinant mengoviruses, nucleic acid derived from the recombinant mengoviruses, and methods of inducing an immune response. The invention is exemplified by a recombinant mengovirus comprising amino acids 299-466 of gp120 of the MN isolate of HIV-I.

Cette invention concerne de mengovirus de recombinaison atténués qui expriment une séquence d'acides aminés hétérologue. Les mengovirus de recombinaison peuvent exprimer des séquences d'acides aminés comprenant des déterminants antigéniques de divers pathogènes viraux et sont utiles comme vaccins vivants contre ces pathogènes chez l'homme et l'animal. Par conséquent cette invention concerne également des vaccins renfermant ces mengovirus de recombinaison ou des protéines de ces derniers, des cellules infectées par les mengovirus de recombinaison, l'acide nucléique dérivé de ces mengovirus de recombinaison et des procédés permettant d'induire une réponse immunitaire. Cette invention concerne plus particulièrement un mengovirus de recombinaison comprenant les acides aminés 299-466 de gp120 de l'isolat MN du VIH-I.

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