A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/116 (2006.01) A61K 39/09 (2006.01) A61K 39/095 (2006.01) A61K 39/385 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01)
Patent
CA 2758921
This disclosure relates to vaccine formulations comprising an immunogenic composition for inducing antibodies to both S. pneumoniae and N. meningitides in a subject. In a preferred aspect, the immunogenic composition comprises covalently conjugated recombinant PsaA ("rPsaA") from S. pneumoniae and capsular polysaccharide from N. meningitidis serogroup C. This disclosure further relates to methods for producing the immunogenic composition as well as methods for their use.
La présente invention concerne des formulations vaccinales comprenant une composition immunogène destinée à induire des anticorps dirigés à la fois contre S. pneumoniae et N. meningitidis chez un sujet. Dans un aspect préféré, la composition immunogène comprend du PsaA recombinant (« rPsaA ») conjugué de manière covalente issu de S. pneumoniae et un polysaccharide capsulaire issu de N. meningitidis du sérogroupe C. Cette invention a en outre pour objet des méthodes de production de la composition immunogène ainsi des méthodes pour leur utilisation.
Lee Che-Hung Robert
Tai Stanley Shih-Peng
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Howard University
The United States Of America Department Of Health And Human Serv
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