Meningococcal fhbp polypeptides

Details Meningococcal fhbp polypeptides Meningococcal fhbp polypeptides

C - Chemistry, Metallurgy

07

K

C07K 14/22 (2006.01) A61K 39/095 (2006.01)

Patent

CA 2716212

fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is selected or engineered to have a sequence which can elicit broad-spectrum bactericidal anti-meningococcal antibodies after administration to a host animal.

Linvention concerne une protéine fHBP dans Neisseria meningitidis. Trois familles de fHBP sont connues. Pour augmenter la capacité dune protéine fHBP à produire des anticorps qui interagissent entre les familles, on choisit ou construit une fHBP pour obtenir une séquence qui peut produire des anticorps anti-méningocoques bactéricides à large spectre après ladministration à un animal hôte.

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