Meningococcus adhesins nada, app and orf 40

Details Meningococcus adhesins nada, app and orf 40 Meningococcus adhesins nada, app and orf 40

C - Chemistry, Metallurgy

07

K

C07K 14/22 (2006.01) A61K 39/095 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2452836

NadA, App and ORF40 function as adhesins in N.meningitidis. Adhesion can be modulated by targeting these three proteins. NadA allelic variants are disclosed. Autoproteolytic cleavage of App is disclosed, as is removal of the activity by mutagenesis. App is processed and secreted into culture medium when expressed in E.coli. Mature App proteins are disclosed. Knockout mutants are disclosed. Vesicles from non-Neisserial hosts with heterologous adhesin expression are disclosed.

La NadA, l'App et l'ORF40 font office d'adhésines dans N. meningitidis. L'adhésion peut être modulée par ciblage de ces trois protéines. L'invention concerne des variantes alléliques de la NadA. L'invention concerne également le clivage autoprotéolytique de l'App, ainsi que la suppression de l'activité par mutagénèse. L'App est traitée et sécrétée dans un milieu de culture lorsqu'elle est exprimée dans l'E. coli. L'invention a trait à des protéines App matures, ainsi qu'à des mutants inactivés et à des vésicules issues d'hôtes de type non-Neisseria présentant une expression d'adhésine hétérologue.

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