Meningococcus vaccine comprising the valence of bz83 strain

Details Meningococcus vaccine comprising the valence of bz83 strain Meningococcus vaccine comprising the valence of bz83 strain

A - Human Necessities

61

K

A61K 39/095 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2267066

The invention concerns a pharmaceutical composition comprising (i) the subunit of least molecular weight (TbpB) of the human transferrin receptor (HTR) of a Neisseria meningitis strain having a DNA sequence coding for Tbp, (a) which contains two AvaII restriction sites, 3 HincII restriction sites, no VspI restriction site and no XhoI restriction site or (b) from which it is possible to generate by PCR (polymerase chain reaction) using primers P3 of formula 5'- AAGACCAAGGCGGATACGGTTTTGC-3' and P4 of formula 5'-GAAGACGAGTCGGAAACAAAGGGATG- 3', a polynucleotide of 765 to 775 nucleotides. Such a strain is for example the BZ83 strain whereof the DNA sequence coding for TbpB is shown in the SEQ ID NO 1.

L'invention a pour objet une composition pharmaceutique comprenant (i) la sous-unité de moindre poids moléculaire (TbpB) du récepteur de la transferrine humaine (RTH) d'une souche de Neisseria meningitidis possédant une séquence d'ADN codant pour TbpB, (a) qui contient 2 sites de restriction AvaII, 3 sites de restriction HincII, aucun site de restriction VspI et aucun site de restriction XhoI ou (b) à partir de laquelle il est possible de générer par PCR (polymérase chain reaction) à l'aide des amorces P3 de formule 5'-AAGACCAAGGCGGATACGGTTTTGC-3' et P4 de formule 5'-GAAGACGAGTCGGAAACAAAGGGATG-3', un polynucléotide de 765 à 775 nucléotides. Une telle souche est par exemple la souche BZ83 dont la séquence d'ADN codant pour TbpB est montrée dans le SEQ ID NO 1.

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