A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/20 (2006.01)
Patent
CA 2633954
A composite for treating an articular defect includes a hyaluronic acid derivative; and at least one member of the group consisting of a cell, a cellular growth factor and a cellular differentiation factor, which is impregnated in, or coupled to. the hyaluronic acid derivative. In one embodiment, carboxyl functionalities of the hyaluronic acid derivative are each independently derivatized to include an N-acylurea or O-acyl isourea, or both N-acylurea and O-acyl isourea. In another embodiment, the hyaluronic acid derivative is prepared by reacting an uncrosslinked hyaluronic acid with a biscarbodimide in the presence of a pH buffer in a range of between about 4 and about 8. The composite can be used for regenerating or stimulating regeneration of meniscal tissues in a subject in need thereof.
L'INVENTION CONCERNE UN COMPOSITE DESTINE AU TRAITEMENT D'UN DEFAUT ARTICULAIRE QUI CONTIENT UN DERIVE D'ACIDE HYALURONIQUE; ET AU MOINS UN ELEMENT DU GROUPE CONSTITUE D'UNE CELLULE, D'UN FACTEUR DE CROISSANCE ET D'UN FACTEUR DE DIFFERENCIATION CELLULAIRE, QUI EST IMPREGNE DANS, OU COUPLE AU DERIVE D'ACIDE HYALURONIQUE. DANS L'UN DES MODES DE REALISATION, DES FONCTIONNALITES CARBOXYLES DU DERIVE D'ACIDE HYALURONIQUE SONT CHACUNE DERIVEES DE FAÇON INDEPENDANTE DE MANIERE A INCLURE DU N-ACYLUREE OU DE L'O-ACYL-ISOUREE, OU LES DEUX. DANS UN AUTRE MODE DE REALISATION, LE DERIVE D'ACIDE HYALURONIQUE EST PREPARE PAR MISE EN REACTION D'UN ACIDE HYALURONIQUE NON RETICULE AVEC UN BISCARBODIIMIDE EN PRESENCE D'UN TAMPON DE PH COMPRIS ENTRE ENVIRON 4 ET 8. LE COMPOSITE PEUT ETRE UTILISE EN VUE DE REGENERER OU DE STIMULER LA REGENERATION DES TISSUS MENISQUAUX CHEZ UN SUJET LE NECESSITANT.
Sadozai Khalid K.
Toth Carol A.
Anika Therapeutics Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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