Mercapto and seleno derivatives as inhibitors of nitric...

A - Human Necessities – 61 – K

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A61K 31/155 (2006.01) A61K 31/195 (2006.01) A61K 31/198 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 31/54 (2006.01)

Patent

CA 2214601

This invention is directed to a pharmacologically acceptable composition for inhibiting nitric oxide synthase in a mammal, which includes a mercapto or seleno derivative and a pharmaceutically acceptable carrier. The invention also concerns a method of inhibiting nitric oxide synthase, selectively inhibiting the inducible isoform of nitric oxide synthase, and treating various conditions where there is an advantage in inhibiting nitric oxide biosynthesis. The method includes the step of administering to a mammal a mercapto or seleno derivative in pure form or in a pharmaceutically acceptable carrier.

La présente invention décrit une composition pharmaceutiquement acceptable pour inhiber la synthase de l'oxyde nitrique chez un mammifère, qui comporte un dérivé de mercapto ou séléno et un excipient pharmaceutiquement acceptable. L'invention concerne également une méthode d'inhibition de la synthase de l'oxyde nitrique, d'inhibition sélective de l'isoforme inductible de la synthase de l'oxyde nitrique et de traitement de divers états pour lesquels il est avantageux d'inhiber la biosynthèse de l'oxyde nitrique. La méthode comprend une étape consistant à administrer à un mammifère un dérivé de mercapto ou séléno sous une forme pure ou avec un excipient pharmaceutiquement acceptable.

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