Mercapto-phenyl-naphthyl-methane derivatives and preparation...

Details Mercapto-phenyl-naphthyl-methane derivatives and preparation... Mercapto-phenyl-naphthyl-methane derivatives and preparation...

C - Chemistry, Metallurgy

07

C

C07C 317/22 (2006.01) A61K 31/10 (2006.01) A61K 31/12 (2006.01) A61K 31/145 (2006.01) A61K 31/222 (2006.01) A61K 31/40 (2006.01) A61K 31/4453 (2006.01) A61P 5/30 (2006.01) C07C 317/24 (2006.01) C07C 323/19 (2006.01) C07C 323/22 (2006.01) C07C 323/25 (2006.01) C07D 295/088 (2006.01)

Patent

CA 2524568

The present invention relates to the field of pharmaceuticals and organic chemistry and provides novel mercapto phenyl naphthyl methane derivatives, their pharmaceutically acceptable salts and compositions and preparation thereof, that are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.

L'invention concerne le domaine des produits pharmaceutiques et de la chimie organique et fournit de nouveaux dérivés de mercapto-phényle-naphthyle-méthane, leurs sels pharmaceutiquement acceptables et leurs compositions et préparations utiles pour prévenir ou traiter différents états pathologiques associés à des maladies dépendantes de l'oestrogène ou des syndromes associés à l'ostéoporose, les pertes osseuses, la formation osseuse, les troubles cardio-vasculaires, les troubles neurodégénératifs, les troubles de la ménopause, les troubles physiologiques, les troubles diabétiques, le carcinome de la prostate, le cancer du sein, le cancer de l'utérus, le cancer du col de l'utérus et du côlon, les menaces d'avortement spontané ou l'avortement habituel, l'obésité, le développement ou la fonction ovarienne, la lactation et la dépression post-partum.

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