C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/55 (2006.01) A61P 9/04 (2006.01)
Patent
CA 2443488
This invention discloses and claims a series of mercaptoacetylamide derivatives of formula (I). Also disclosed and claimed are pharmaceutical compositions incorporating these compounds and processes for preparing said compounds. The use of said compounds for inhibition of the enzymes angiotensin converting enzyme and neutral endopeptidase, and for the treatment of hypertension and congestive heart failure are also disclosed and claimed.
L'invention concerne une série de dérivés de mercaptoacétylamide de formule (I). L'invention concerne en outre des compositions pharmaceutiques contenant ces composés, ainsi que des procédés de préparation de ces composés. L'invention concerne enfin l'utilisation de ces composés pour inhiber l'enzyme de conversion de l'angiotensine et l'endopeptidase neutre et pour traiter l'hypertension et l'insuffisance cardiaque globale.
Anderson Barbara Ann
Flynn Gary A.
Gerken Manfred
Jablonka Bernd
Kleemann Heinz-Werner
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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