Mercaptoacylamino acids as metallo-beta-lactamase inhibitors

Details Mercaptoacylamino acids as metallo-beta-lactamase inhibitors Mercaptoacylamino acids as metallo-beta-lactamase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 323/60 (2006.01) A61K 31/195 (2006.01)

Patent

CA 2298682

Amino acid derivatives of formula (I): R4S-C(R5R6)-C(=CHR3)-CON(R2)-CH(R1)- CO2R, in which the variables are as defined in claim 1, having metallo-$G(b)- lactamase inhibitory properties, useful for the treatment of infections in animals.

L'invention concerne des dérivés d'acides aminés représentés par la formule (I) et présentant des propriétés inhibitrices dirigéescontre les métallo-.beta.-lactamases, propriétés qui sont utiles dans le traitement des infections chez l'animal. Dans la formule (I), R¿4?S-C(R¿5?R¿6?)-C(=CHR¿3?)-CON(R¿2?)-CH(R¿1?)-CO¿2?R, les variables sont telles que définies dans la revendication 1.

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