Merosin, nucleic acids encoding, fragments and uses thereof

Details Merosin, nucleic acids encoding, fragments and uses thereof Merosin, nucleic acids encoding, fragments and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/39 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 1/22 (2006.01) C07K 14/78 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2074361

2074361 9111462 PCTABS00006 This invention provides a purified protein, having an apparent molecular weight of about 800 kDa, designated merosin. Also provided is a substantially pure heterotrimeric laminin variant comprising the structure M-X-B2, wherein M is the M polypeptide of merosin; X is selected from the group consisting of the B1 chain of laminin and S-laminin; and B2 is the B2 chain of laminin. Also provided is an isolated nucleic acid sequence which encodes merosin. The invention further provides antibodies, vectors, and the expression of recombinant proteins by use of a host vector system. The invention also provides the use of merosin to promote neurite growth.

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