C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/02 (2006.01) C12N 5/077 (2010.01) A61K 35/12 (2006.01) A61K 35/32 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2453068
This invention provides populations of mesenchymal cells obtained from pluripotent stem cells by differentiating them ex vivo. Multipotent mesenchymal cells can in turn be differentiated into more specialized cell types such as osteoblasts, with properties that make them suitable for reconstituting musculoskeletal cell function in an individual. The compositions, methods, and techniques described in this disclosure can be used for a variety of commercially important diagnostic, drug screening, and therapeutic applications.
L'invention concerne des populations de cellules mésenchymateuses obtenues à partir de cellules souches pluripotentes par différentiation de ces dernières ex vivo. Des cellules mésenchymateuses pluripotentes peuvent être différenciées en types de cellules plus spécialisées, telles que des ostéoblastes, présentant des propriétés qui les rendent appropriées pour la reconstitution de fonction de cellules musculo-squelettiques chez un individu. Les compositions, procédés et techniques de l'invention peuvent être utilisés pour une variété commercialement importantes d'applications, à des fins de diagnostic, de criblage de médicaments et à des fins thérapeutiques.
Thies R. Scott
Xu Chunhui
Geron Corporation
Smart & Biggar
LandOfFree
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