Mesenchymal stem cells and methods of use thereof

Details Mesenchymal stem cells and methods of use thereof Mesenchymal stem cells and methods of use thereof

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 35/12 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2505251

The Invention provides compositions and methods of enhancing the viability of primary stem cells and enhancing the engraftment of transplanted stem cells into a mammalian recipient. Accordingly, the invention includes a method of regenerating a mesenchymally-derived tissue by contacting the tissue with a composition containing an isolated adult mesenchymal stem cell, which are apoptosis-resistant. The mesenchymal stem cell is an adult cell obtained from an adult bone marrow.

L'invention concerne des compositions et des procédés d'amélioration de la viabilité de cellules souches primaires et d'amélioration de la prise de greffe de cellules souches transplantées chez un receveur mammifère. L'invention concerne un procédé de régénération d'un mésenchyme par la mise en contact dudit mésenchyme avec une composition contenant une cellule souche mésenchymateuse adulte isolée, qui s'avèrent résistants à l'apoptose. La cellule souche mésenchymateuse est une cellule adulte obtenue à partir d'une moelle osseuse adulte.

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