Mesenchymal stem cells as immunosuppressants

Details Mesenchymal stem cells as immunosuppressants Mesenchymal stem cells as immunosuppressants

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2326838

The present invention provides a method to modulate immune responses using antigen presenting human mesenchymal stem cells to induce specific T cell anergy. The present invention also provides a method to modulate immune responses using human mesenchymal stem cells as a platform to express molecules which will induce T cell anergy.

La présente invention a trait a une méthode de modulation de réponses immunes utilisant des cellules souches mésenchimateuses humaines de présentation d'antigène pour induire une anergie des lymphocytes T spécifiques. La présente invention a également trait à une méthode de modulation de réponses immunes utilisant des cellules souches mésenchimateuses humaines comme plate-forme pour exprimer des molécules induisant une anergie des lymphocytes T.

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