Mesenchymal stem cells expressing tnf-.alpha. receptors

Details Mesenchymal stem cells expressing tnf-.alpha. receptors Mesenchymal stem cells expressing tnf-.alpha. receptors

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01)

Patent

CA 2635915

Mesenchymal stem cells which express TNF-.alpha. receptor Type I in an amount of at least 13 pg/106 cells. Such mesenchymal stem cells inhibit the proliferation of lymphocytes and may be employed, in particular, in the treatment of graft-versus-host disease.

La présente invention concerne des cellules souches mésenchymateuses qui expriment le récepteur de type I du TNF-.alpha. en une quantité s'élevant à au moins 13 pg/106 cellules. De telles cellules souches mésenchymateuses inhibent la prolifération de lymphocytes et peuvent servir en particulier à traiter la maladie du greffon contre l'hôte.

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