Mesenchymal stem cells producing inhibitory rna for disease...

Details Mesenchymal stem cells producing inhibitory rna for disease... Mesenchymal stem cells producing inhibitory rna for disease...

C - Chemistry, Metallurgy

12

N

C12N 5/0775 (2010.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2756670

Compositions and methods for delivering a siRNA, dsRNA, or miRNA polynucleotide into a target cell comprising contacting the target cell with a mesenchymal stem cell, which mesenchymal stem cell comprises an exogenous DNA sequence expressing the siRNA or dsRNA polynucleotide, thereby delivering the siRNA, dsRNA, or miRNA polynucleotide to the target cell through a cellular protrusion or a microvesicle.

La présente invention concerne des compositions et des procédés permettant d'introduire un polynucléotide de type ARNsi, ARNdb, ou ARNmi dans une cellule cible, cela comprenant la mise en contact de ladite cellule cible avec une cellule souche mésenchymateuse, ladite cellule souche mésenchymateuse comprenant une séquence d'ADN exogène exprimant le polynucléotide de type ARNsi ou ARNdb, cela permettant l'introduction du polynucléotide de type ARNsi, ARNdb ou ARNmi dans la cellule cible via une protrusion cellulaire ou une microvésicule.

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