C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) C07D 471/08 (2006.01) C07D 471/18 (2006.01) C07D 487/08 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2082415
ABSTRACT OF THE DISCLOSURE The meso-azacyclic aromatic acid amides and esters of the present invention are useful in the treatment of the central nervous system and gastrointestinal motility disorders such as gastroesophagaal reflux, non ulcer dyspepsia, delayed gastric emptying, ileus, irritable bowel syndrome, and the like. Additionally, the compounds of the present invention find utility as antagonists of serotonin 5-HT3 receptors. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and/or withdrawal, irritable bowel syndrome, emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
Becker Daniel P.
Flynn Daniel L.
Moormann Alan E.
Nosal Roger
Villamil Clara I.
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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