Mesothelial cell gene therapy

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/85 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) C07K 14/61 (2006.01) C12N 5/10 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2164424

Methods and pharmaceutical compositions for modifying the mesothelial cells of a mammalian recipient in situ are provided. The methods include forming a mesothelial cell expression system in vivo or ex vivo and administering the expression system to the mammalian recipient (by way of the body cavities normally lined by mesothelial cells). The mesothelial cell expression system is useful for the localized and systemic delivery of therapeutic agents in situ.

L'invention se rapporte à des procédés et à des compositions pharmaceutiques permettant la modification in situ des cellules mésothéliales d'un receveur mammifère. Ces procédés comprennent la formation d'un système d'expression de la cellule mésothéliale in vivo ou ex vivo et l'implantation dudit système au receveur mammifère (par la voie des cavités corporelles normalement tapissées de cellules mésothéliales). Le système permettant l'expression de la cellule mésothéliale est utile pour la libération localisée et systémique d'agents thérapeutiques in situ.

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