Mesothelin vaccines and model systems

Details Mesothelin vaccines and model systems Mesothelin vaccines and model systems

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 31/7088 (2006.01) A61K 38/08 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2492160

Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either polynucleotide- or polypeptide-based. Carriers for raising a cytolytic T cell response include bacteria and viruses. A mouse model for testing vaccines and other anti-tumor therapeutics and prophylactics comprises a strongly mesothelin-expressing, transformed peritoneal cell line.

Selon l'invention, la mésothéline peut être utilisée en tant que cible immunothérapeutique. Elle induit une réponse des lymphocytes T cytolytiques. Certaines parties de la mésothéline induisant ces réponses sont identifiées. Les vaccins peuvent être à base de polynucléotides ou de polypeptides. Des excipients destinés à promouvoir une réponse des lymphocytes T cytolytiques peuvent notamment être des bactéries et des virus. Un modèle de souris destiné à tester des vaccins ainsi que d'autres traitements et prophylactiques antitumoraux présente une ligne de cellules péritonéales transformées à forte expression de la mésothéline.

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