Meta-substituted phenyl alanine derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 211/16 (2006.01) A61K 31/215 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 38/04 (2006.01) C07C 311/19 (2006.01) C07C 327/58 (2006.01) C07D 211/60 (2006.01) C07D 211/62 (2006.01) C07D 215/36 (2006.01) C07D 215/50 (2006.01) C07D 217/26 (2006.01) C07D 295/185 (2006.01) C07D 401/12 (2006.01) C07K 5/00 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/068 (2006.01) C07K 5/083 (2006.01) C07K 5/09 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2073776

ABSTRACT D,L-, L- and D-phenyl alanine derivatives of formula (I) defined in claim 1 in which R1 is an amidino-, guani- dino-, oxamidino-, aminomethyl- or amino group have been discovered which effectively prevent blood coagulation or thrombosis. The antithrombotically active compounds have low toxicity and may be administered by mouth, subcu- taneously or intravenously.

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