Metabolic engineering of polyhydroxyalkanoate monomer synthases

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) C12N 9/00 (2006.01) C12N 15/31 (2006.01) C12N 15/52 (2006.01) C12N 15/86 (2006.01) C12N 15/866 (2006.01) C12P 7/62 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2240360

A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase.

Cette invention se rapporte à un nouveau procédé de synthèse de polyhydroxyalcanoates. L'invention se rapporte également à un procédé de synthèse d'une synthase monomère de polyhydroxyalcanoates recombinée. Ces synthases recombinées de polyhydroxyalcanoates sont dérivées de synthases d'acides gras multifonctionnelles ou de synthases polycétidiques et elles produisent des acides hydroxyacyliques susceptibles d'être polymérisés par une synthase de polyhydroxyalcanoates.

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