C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/14 (2006.01) C12N 1/18 (2006.01) C12N 9/92 (2006.01) C12P 7/00 (2006.01) C12P 7/08 (2006.01)
Patent
CA 2573483
The present invention relates to further genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers the host cell the ability of isomerising xylose to xylulose. The further genetic modifications are aimed at improving the efficiency of xylose metabolism and include e.g. reduction of unspecific aldose reductase activity, increased xylulose kinase activity and increased flux of the pentose phosphate pathway. The modified host cells of the invention are suitable for the production of a wide variety of fermentation products, including ethanol, in fermentation processes in which a source of xylose or a source of xylose and glucose are used as carbon source.
L'invention concerne de nouvelles modifications génétiques dans des cellules hôtes eucaryotes qui ont été transformées de manière à exprimer un xylose isomérase qui confère à la cellule hôte l'aptitude d'isomériser le xylose en xylulose. Lesdites nouvelles modifications génétiques visent l'amélioration de l'efficacité du métabolisme du xylose et consistent notamment en la réduction de l'activité de la réductase d'aldose non spécifique, de l'activité accrue de la xylulose kinase et du flux accru du processus pentose phosphate. Lesdites cellules hôtes modifiées conviennent pour la production d'un grand nombre de produits de fermentation, y compris l'éthanol, dans des procédés de fermentation dans lesquels une source de xylose ou une source de xylose et glucose servent de source de carbone.
de Laat Wilhelmus Theodorus Antonius Maria
Kuyper Sipko Maarten
Pronk Jacobus Thomas
Van Dijken Johannes Pieter
Winkler Aaron Adriaan
Gowling Lafleur Henderson Llp
Technische Universiteit Delft
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