Metabolite derivatives of the hdac inhibitor fk228

Details Metabolite derivatives of the hdac inhibitor fk228 Metabolite derivatives of the hdac inhibitor fk228

A - Human Necessities

61

K

A61K 38/12 (2006.01) C07K 5/12 (2006.01)

Patent

CA 2630216

The present invention relates to HDAC inhibitor derivatives, particularly derivatives of the free thiol of metabolites of the HDAC inhibitor FK228, pharmaceutical compositions thereof, and to methods of using such derivatives and pharmaceutical compositions thereof in the treatment of diseases associated with HDAC, in particular, tumor or cell proliferation diseases.

L'invention concerne des dérivés de l'inhibiteur de HDAC, notamment des dérivés du thiol libre des métabolites de l'inhibiteur de HDAC FK228, des compositions pharmaceutiques de ceux-ci et des procédés d'utilisation de tels dérivés et des compositions pharmaceutiques de ceux-ci dans le traitement de maladies associées à HDAC, notamment des maladies de prolifération tumorale ou cellulaire.

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