Metabolite detection using magnetic resonance

G - Physics – 01 – N

Patent

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G01N 24/00 (2006.01) G01N 24/08 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2663933

Methods using magnetic resonance, such as nuclear magnetic resonance (NMR) spectroscopy or magnetic resonance imaging (MRI), are provided for detecting metabolites in a sample. The methods are useful for the diagnosis or prognosis of a disease such as cancer and can also be used to determine or monitor a treatment protocol. The methods are useful in characterizing speciation in biological samples where mixtures are often encountered and chemical shifts of the same structural group of similar molecules can produce complicated overlapping resonances.

La présente invention concerne des procédés utilisant la résonance magnétique, telle que la spectrométrie de résonance magnétique nucléaire (RMN) ou l'imagerie par résonance magnétique (IRM), permettant de détecter des métabolites dans un échantillon. Lesdits procédés sont utiles pour diagnostiquer ou pronostiquer une maladie, telle que le cancer, et peuvent également servir pour déterminer ou surveiller un protocole de traitement. Ces procédés sont également utiles pour caractériser la spéciation dans des échantillons biologiques dans lesquels on rencontre souvent des mélanges, et dans lesquels des déplacements chimiques du même groupe structurel de molécules similaires peuvent produire des résonances de débordement complexes.

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