Metabolites of ecteinascidin 743

Details Metabolites of ecteinascidin 743 Metabolites of ecteinascidin 743

C - Chemistry, Metallurgy

07

D

C07D 515/22 (2006.01) A61K 31/36 (2006.01) A61K 31/4985 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) C07D 217/10 (2006.01) C07D 317/64 (2006.01)

Patent

CA 2331593

The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as "ETM" followed by a numeric value which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204. The structures of these ecteinascidin metabolites are shown as ETM 305, ETM 204 and ETM 775.

L'invention concerne la purification et la détermination de la structure de plusieurs produits du métabolisme de Et 743 par le cytochrome CYP3A4. Ces composés sont désignés ci-après par l'abréviation ETM suivie d'une valeur numérique qui représente la masse moléculaire approximative. A ce jour, trois composés ont été identifiés, à savoir ETM 305, ETM 775 et ETM 204. Les structures de ces métabolites d'ectéinascidine se présentent de la façon suivante: (ETM 305), (ETM 775) et (ETM 204).

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