Metabolites of the janus kinase inhibitor...

Details Metabolites of the janus kinase inhibitor... Metabolites of the janus kinase inhibitor...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2689158

The present invention provides active metablites of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

L'invention concerne des métabolites actifs de 3-(4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile qui modulent l'activité de Janus kinases et sont utiles dans le traitement des maladies relatives à l'activité de Janus kinases comprenant, par exemple, des maladies immunologiques, des affections cutanées, des troubles prolifératifs de myéloïde, des cancers, et d'autres maladies.

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