Metabolites of wortmannin analogs and methods of using the same

Details Metabolites of wortmannin analogs and methods of using the same Metabolites of wortmannin analogs and methods of using the same

C - Chemistry, Metallurgy

07

J

C07J 43/00 (2006.01) A61K 31/352 (2006.01) A61K 31/58 (2006.01) C07J 41/00 (2006.01)

Patent

CA 2636040

Novel metabolites of wortmannin and wortmannin analogs and their use in inhibiting PI-3 kinase activity in mammals and the treatment and prevention of cancer or tumor formation in a subject are described herein.

La présente invention concerne de nouveaux métabolites de la wortmannine et des analogues de la wortmannine ainsi que leur utilisation en vue d'inhiber l'activité de la kinase PI-3 chez les mammifères et lors du traitement et de la prévention du cancer ou de la formation d'une tumeur chez un sujet.

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