Metabotropic glutamate receptor-5 modulators

Details Metabotropic glutamate receptor-5 modulators Metabotropic glutamate receptor-5 modulators

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/423 (2006.01) A61K 31/4353 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 263/57 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01) C07D 413/10 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2468067

Phenyl compounds substituted at the 1-position with a fused bicyclo moeity formed from a five-membered heterocycle fused to a six-membered carbocycle, to a six-membered aryl, or to a six-membered hetaryl, and further optionally substituted at the 3,4 positions, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, and panic, as well as in the treatment of pain and other diseases.

L'invention porte sur des composés phénylés substitués en position 1 par un fragment bicyclo condensé, formés à partir d'un hétérocycle à 5 éléments transformé en un carbocycle à six éléments, en un aryle à six éléments ou un hétaryle à six éléments, puis facultativement substitués en position 3, 4. Ces modulateurs du mGluR5 sont utilisables pour le traitement de troubles psychiatriques et de l'humeur, tels que par exemple la schizophrénie, l'angoisse, la dépression, et la panique, ainsi que pour le traitement de la douleur et d'autres maladies.

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