Metal-binding compounds and uses therefor

Details Metal-binding compounds and uses therefor Metal-binding compounds and uses therefor

C - Chemistry, Metallurgy

07

K

C07K 7/00 (2006.01) C07K 5/113 (2006.01) C07K 14/76 (2006.01) C07K 14/795 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2385551

The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS in a tissue or an organ that has been removed from an animal. This method comprising contacting the tissue or organ with a solution containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.

L'invention concerne une méthode de réduction de la détérioration due aux espèces réactives dérivées de l'oxygène (ROS) chez un animal. L'invention concerne également une méthode de réduction de la concentration d'un métal chez un animal. Ces méthodes consistent à administrer à l'animal une dose efficace d'un composé de fixation de métal tel que décrit également dans la demande. L'invention concerne également une méthode de réduction de la détérioration engendrée par ROS dans un tissu ou un organe ayant été prélevé sur un animal. Cette méthode consiste à mettre le tissu ou l'organe en contact avec une solution contenant une dose efficace d'un composé de fixation de métal de l'invention. L'invention concerne en outre de nouveaux composés de fixation de métal, des compositions pharmaceutiques contenant les composés de fixation de métal ainsi que des matériels comprenant un récipient renfermant un composé de fixation de métal de l'invention.

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