Metal-carborane complexes for radioimaging and radiotherapy...

Details Metal-carborane complexes for radioimaging and radiotherapy... Metal-carborane complexes for radioimaging and radiotherapy...

C - Chemistry, Metallurgy

07

F

C07F 13/00 (2006.01) A61K 51/00 (2006.01) C07B 59/00 (2006.01)

Patent

CA 2387436

The present invention relates to a new method for the preparation of radiopharmaceuticals based on technetium and rhenium. The method involves the reaction of a salt of the formula [ M(CO)3(X m)3](1+3m), wherein M is selected from a radioisotope of rhenium, technetium and any other radioisotope that binds in a similar fashion, X is any suitable ligand and m is the formal charge for ligand X, with a nido-dicarbollide dianion of the formula [nido-(C2B9H11)]2- and functional derivatives thereof. The method has been shown to be applicable to the preparation of radiopharmaceuticals at the tracer level.

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