C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/04 (2006.01) C07K 1/22 (2006.01) C07K 14/55 (2006.01)
Patent
CA 2524693
Use of an activated solid phase and an anchoring part which is attached to a peptide for solid phase peptide synthesis, wherein the anchoring part is coordinatively and reversibly attached to the activated solid phase. Furthermore provided is a process for competitively detachment of said anchoring part, for purification and refolding of said peptides. Provided are peptides with an anchoring part for coordinative and reversible attachment of said peptides to an activated solid phase. In preferred embodiments, the linkage between peptide(s) and solid phase consists of a metal chelate complex. The immobilized peptide is subjected to synthetic steps for sequence elongation (i. e. is a growing peptide). The preferred metal ion for chelate complexes is Cu(2+), and the preferred ligand on resin is 1,10-phenantroline.
L'invention porte sur l'utilisation d'une phase solide activée et d'une fraction d'ancrage fixée sur un peptide, pour la synthèse de peptides en phase solide, la fraction d'ancrage étant fixée par d'une liaison coordinative et réversible sur la phase solide activée. L'invention concerne également un procédé de détachement compétitif de ladite fraction d'ancrage, permettant la purification et le repliement desdits peptides. L'invention concerne en outre des peptides qui comprennent une fraction d'ancrage leur permettant de se fixer de manière coordinative et réversible sur une phase solide activée.
Bracht Franz-Peter
Frank Hans-Georg
Haberl Udo
Rybka Andreas
Aplagen Gmbh
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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