Metal complexes

Details Metal complexes Metal complexes

C - Chemistry, Metallurgy

07

D

C07D 213/69 (2006.01) C07D 309/40 (2006.01) C07F 5/00 (2006.01) A61K 43/00 (1990.01) A61K 49/02 (1990.01)

Patent

CA 2058288

2058288 9114664 PCTABS00007 Neutral 3:1 ligand:metal (III) complexes, in which the trivalent metal cation is a radioactive isotope of indium or gallium and each ligand is separately provided by a compound being: (1) a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms is replaced by an aliphatic hydrocarbon group of one to six carbon atoms or such a group substituted by one or more groups selected from fluoro, hydroxy and aliphatic hydrocarbyloxy groups but excluding 3-hydroxy-2-methyl-4-pyrone; or (2) 3-hydroxypyridin-2-one or a 3-hydroxypyridin-2-one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by one or more substituents selected from aliphatic acyl, alkoxy, cycloalkoxy, aliphatic amide, aliphatic ester, halogen and hydroxy groups and optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms is replaced by one of said substituents, by an aliphatic hydrocarbon group of 1 to 6 carbon atoms, or by an aliphatic hydrocarbon group substituted by an alkoxy, cycloalkoxy, aliphatic ester or hydroxy group or by one or more halogen groups; are of value in therapy and particularly in diagnosis, especially in the context of cell labelling.

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