Metal compounds, mixed or sulphated, as phosphate binders

Details Metal compounds, mixed or sulphated, as phosphate binders Metal compounds, mixed or sulphated, as phosphate binders

A - Human Necessities

61

K

A61K 33/26 (2006.01) A61K 33/06 (2006.01) A61K 33/24 (2006.01)

Patent

CA 2303820

A mixed metal compound for pharmaceutical use is free from aluminium and has a phosphate binding capacity of at least 30 %, by weight of the total weight of phosphate present, over a pH range of from 2-8. The compound is especially useful for treatment of hyperphosphataemia. The metals are preferably iron (III) and at least one of calcium, magnesium, lanthanum and cerium. A metal sulphate for pharmaceutical use is selected from at least one of calcium, lanthanum and cerium sulphate compounds and has a phosphate binding capacity of at least 30 % by weight of the total phosphate present, over a pH range from 2-8.

La présente invention concerne un composé métallique mélangé exempt d'aluminium, utilisé en pharmacie. Ce composé possède une capacité de liaison de phosphate d'au moins 30 % en poids du poidstotal de phosphate présent, sur une plage de pH de 2-8. Ce composé est utilisé en particulier pour le traitement de l'hyperphosphatémie. Les métaux sont, de préférence, du fer (III) et au moins du calcium, du magnésium, du lanthane et du cérium. Un sulfate métallique à usage pharmaceutique est sélectionné au moins à partir de composés de sulfate de cérium, de lanthane et de calcium et possède une capacité de liaison de phosphate d'au moins 30 % en poids de la totalité du phosphate présent, sur une plage de pH de 2-8.

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