Metal-containing ribonucleotide polypeptides

Details Metal-containing ribonucleotide polypeptides Metal-containing ribonucleotide polypeptides

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C07K 1/36 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2196802

Bioactive copper-, zinc- or calcium-containing ribonucleopolypeptides (RNP) are disclosed. They are non-mitogenic morphogenetic agents for blood vessels and have a defined primary structure for intercellular communication containing genetic information. Zn/Ca/Cu-RNP may enzymatically hydrolyse nucleic acids in a controlled manner (controlled nuclease activity) and their bioactivity may be mutually modulated and controlled by means of their Zn/Ca/Cu metal ion content, that acts as a "molecular switch". These compounds selectively stimulate directional growth or morphogenesis of blood vessels in vivo and in vitro and cause neovascularisation of tissues. Also disclosed are a process for preparing and extracting RNP, their use and medicaments.

L'invention concerne des ribonucléopolypeptides (RNP) bioactifs qui contiennent du cuivre, du zinc ou du calcium. Ces ribonucléopolypeptides sont des agents morphogénétiques non mitogènes des vaisseaux sanguins et présentent une structure primaire définie de communication intercellulaire porteuse d'informations génétiques. Les RNP de ZN/Ca/Cu peuvent hydrolyser par voie enzymatique des acides nucléiques de manière régulée (activité de nucléase régulée) et leur bioactivité peut être modulée et régulée par leur teneur en ions métalliques de Zn/Ca/Cu, qui agissent comme des "commutateurs moléculaires". Ces composés stimulent sélectivement la croissance directionnelle ou la morphogenèse des vaisseaux sanguins in vivo et in vitro et provoquent une néovascularisation des tissus. L'invention concerne également un procédé de préparation et d'extraction de RNP, ainsi que leur utilisation et des médicaments.

Affiliated with

Also associated with

Rating

Metal-containing ribonucleotide polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Metal-containing ribonucleotide polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Metal-containing ribonucleotide polypeptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2089560