Metal-enhanced fluorescence-based sensing methods

Details Metal-enhanced fluorescence-based sensing methods Metal-enhanced fluorescence-based sensing methods

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/72 (2006.01) C40B 30/04 (2006.01) C40B 60/00 (2006.01) G01N 21/64 (2006.01)

Patent

CA 2656004

The present invention relates to metallic-surface detection systems for determining target substances including free bilirubin in neonatal serum in the presence of a predominantly high background of bilirubin bound Human Serum Albumin (HSA) or sensing and isolating target nucleotide sequences wherein a fluorescence signal is enhanced by close proximity of the target substances near metallic surfaces.

Systèmes de détection par surface métallique permettant de déterminer des substances cibles, y compris la bilirubine libre dans le sérum néonatal en présence d'un fond fortement prédominant d'albumine de sérum humain lié à la bilirubine ou de détecter et d'isoler des séquences nucléotidiques cibles. On améliore un signal de fluorescence par le positionnement de substances cibles à proximité de surfaces métalliques.

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