Metal implant coated under reduced oxygen concentration with...

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/06 (2006.01) A61F 2/30 (2006.01) A61K 38/18 (2006.01) A61L 27/04 (2006.01) A61L 27/22 (2006.01) A61L 27/28 (2006.01) A61C 8/00 (2006.01) A61F 2/00 (2006.01) A61F 2/32 (2006.01) A61F 2/38 (2006.01) A61F 2/42 (2006.01) A61F 2/44 (2006.01)

Patent

CA 2498512

The present invention relates to a method for producing a device comprising the steps of (a) providing a solution comprising dissolved osteoinductive protein, (b) contacting the solution of the preceding step with a carrier containing a surface of metal or metal alloy, (c) allowing coating of the surface of said carrier with said dissolved protein and (d) drying of the coated carrier obtained in step (c) wherein steps (b) to (d) are carried out under a reduced concentration of oxygen. The invention also encompasses a device obtainable by the method of the present invention. Moreover, the present invention relates to a pharmaceutical composition comprising the said device and to the use of the device for the preparation of a pharmaceutical composition to be used for an accelerated osseointegration and new bone formation. Finally, the present invention relates to a kit comprising the device of the present invention.

L'invention concerne un procédé de production d'un dispositif qui consiste (a) à produire une solution comprenant une protéine ostéoinductive dissoute, (b) à mettre en contact ladite solution avec un porteur contenant une surface métallique ou d'un alliage métallique, (c) à recouvrir la surface dudit porteur de ladite protéine dissoute et (d) à faire sécher ledit porteur revêtu, les étapes (b) à (d) étant exécutées sous une teneur d'oxygène réduite. L'invention concerne également un dispositif obtenu suivant ce procédé. De plus, elle concerne une composition pharmaceutique comprenant ledit dispositif ainsi que l'utilisation de celui-ci pour préparer une composition pharmaceutique pouvant être utilisée dans une osséointégration et nouvelle formation osseuse accélérées. Enfin, l'invention concerne une trousse comprenant ledit dispositif.

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