Metal-interferon-alpha crystals

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/56 (2006.01) A61K 38/21 (2006.01) B01D 9/02 (2006.01) C30B 7/00 (2006.01)

Patent

CA 2156921

The present invention provides for crystalline zinc-interferon alpha-2 (IFN-alpha-2). The present invention further provides for crystalline cobalt-IFN-alpha-2, and crystalline IFN-alpha-2 having a serum half-life of at least about 12 hours when injected into a primate. The present invention further provides for a method for producing a crystalline IFN-alpha-2 comprising forming a soluble metal-IFN-alpha-2 complex, and equilibrating the soluble metal-IFN-alpha-2 complex in solution with an acetate salt of the metal under conditions that will cause the metal-IFN-alpha-2 solution to become supersaturated and form crystalline metal-IFN-alpha-2. The present invention also includes crystalline metal-alpha interferon having monoclinic, plate and needle morphologies.

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