C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/56 (2006.01) A61K 38/21 (2006.01) B01D 9/02 (2006.01) C30B 7/00 (2006.01)
Patent
CA 2156921
The present invention provides for crystalline zinc-interferon alpha-2 (IFN-alpha-2). The present invention further provides for crystalline cobalt-IFN-alpha-2, and crystalline IFN-alpha-2 having a serum half-life of at least about 12 hours when injected into a primate. The present invention further provides for a method for producing a crystalline IFN-alpha-2 comprising forming a soluble metal-IFN-alpha-2 complex, and equilibrating the soluble metal-IFN-alpha-2 complex in solution with an acetate salt of the metal under conditions that will cause the metal-IFN-alpha-2 solution to become supersaturated and form crystalline metal-IFN-alpha-2. The present invention also includes crystalline metal-alpha interferon having monoclinic, plate and needle morphologies.
Hruza Alan
Mcnemar Charles
Nagabhushan Nagamani
Nagabhushan Tattanahalli L.
Reichert Paul
Schering Corporation
Swabey Ogilvy Renault
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