C - Chemistry – Metallurgy – 08 – G
Patent
C - Chemistry, Metallurgy
08
G
C08G 73/02 (2006.01) A61K 31/785 (2006.01) A61K 31/80 (2006.01)
Patent
CA 2042870
The invention is concerned with a metal ion coordinated polyamine resin in which a non-toxic, pharmaceu- tically acceptable chelating metal ion is coordinated with a cross-linked and non-digestible polymeric amine selected from the group consisting of: (a) polyamine resins with a hydrophilic backbone, of the formula: P-[(CH2)nNH]mH or Image (Ia) (Ib) wherein P represents a hydrophilic, cross-linked and non- digestible homopolymer backbone, m is an integer varying from 1 to 10 inclusive, and n, o and p are, independently, integers varying from 2 to 12 inclusive; (b) polyamine resins with a hydrophobic backbone, of the formula: P'-[NH(CH2)n]mNH2 (II) wherein P' represents a hydrophobic, cross-linked and non- digestible homopolymer backbone, m is an integer varying from 0 to 6 inclusive and n is an integer varying from 2 to 12 inclusive; and (c) cross-linked copolymers of a poly- ethylenepolyamine containing from 2 to 6 ethylene units and epichlorohydrin. The metal ion coordinated polyamine resins of the invention are highly efficient sorbents for bile acids and salts and can thus be used for reducing hyper- cholesterolemia in affected humans.
Brown George Ronald
St. Pierre Leon Edward
Wu Gaoming
Yu Youlu
Lowchol Scientific Inc.
Swabey Ogilvy Renault
LandOfFree
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