Metal ion labeling of carrier molecules

Details Metal ion labeling of carrier molecules Metal ion labeling of carrier molecules

C - Chemistry, Metallurgy

07

K

167/40, 167/47,

C07K 17/14 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01) C07K 1/107 (2006.01) G01N 33/532 (2006.01) G01N 33/534 (2006.01)

Patent

CA 1288197

ABSTRACT OF THE DISCLOSURE A conjugate of a protein or polypeptide and a metal ion is prepared by reacting a metal ion transfer complex comprising a chelate of 4,5-dihydroxyl-m-benzenedi- sulfonic acid or a salt thereof with a protein or polypeptide that is covalently bound to an exogenous chelating group having a greater affinity than 4,5-dihydroxyl-m-benzenedisulfonic acid for the metal ion.

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