Metalloenzyme inhibitors using metal binding moieties in...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/4406 (2006.01) A61K 31/122 (2006.01) A61K 31/18 (2006.01) A61K 31/33 (2006.01) A61K 31/35 (2006.01) A61K 31/352 (2006.01) A61K 31/36 (2006.01) A61K 31/37 (2006.01) A61K 31/381 (2006.01) A61K 31/382 (2006.01) A61K 31/39 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) A61K 31/431 (2006.01) A61K 31/433 (2006.01) A61K 31/437 (2006.01) A61K 31/44 (2006.01) A61K 31/55 (2006.01) A61K 31/5513 (2006.01)

Patent

CA 2708281

The presently disclosed subject matter is described to metalloenzyme inhibitors having metal binding moieties linked to a targeting moiety through a linking group or a direct bond, method of screening for metalloenzyme inhibitors, and methods for treating a metalloenzyme related disorder by administering a metalloenzyme inhibitor to a subject in need of treatment thereof.

La présente invention porte sur des inhibiteurs de métalloenzymes ayant des fractions de liaison à un métal liées à une fraction de ciblage par un groupe de liaison ou une liaison directe, sur un procédé de criblage pour des inhibiteurs de métalloenzymes, et sur des procédés pour traiter un trouble apparenté à une métalloenzymes par l'administration d'un inhibiteur de métalloenzyme à un sujet nécessitant un tel traitement.

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