Metalloprotease peptide substrates and methods

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/37 (2006.01) A61K 51/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/705 (2006.01) C07K 14/81 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) G01N 33/52 (2006.01) G01N 33/533 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2414061

The present invention describes natural or synthetic peptide substrates of the metalloproteases, ADAM8, ADAM15 and MDC-L. The invention also describes methods using these peptides to discover pharmaceutical agents that modulate these proteases.

L'invention concerne des substrats peptidiques naturels ou synthétiques, des métalloprotéinases, ADAM8, ADAM15 et DMC-L. Elle concerne également des procédés mettant en application ces peptides afin de rechercher des agents pharmaceutiques modulant ces protéinases.

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