A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/65 (2006.01) A61K 31/00 (2006.01) A61K 45/06 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 35/00 (2006.01) A61K 9/00 (2006.01)
Patent
CA 2399418
Use of a compound for the manufacture of a medicament for the treatment of a respiratory disease involving tissue destruction, wherein a compound has an inhibitory activity of greater than 50 % inhibition of MMP1 or MMP2 or MMP8 or MMP9 at less than 100 µM concentration in an enzyme assay and which also downregulates in COPD lung tissue MMP1 or MMP2 or MMP8 or MMP9 to less than 50 % of untreated levels at 100 µM.
L'invention concerne un composé utilisé dans la fabrication d'un médicament utilisé dans le traitement d'une maladie respiratoire associée à la destruction des tissus. Ce composé possède une activité d'inhibition supérieure à 50 % de l'inhibition de MMP1, MMP2, MMP8 ou MMP9 à une concentration inférieure à 100 µM dans un test d'activité enzymatique. Il participe également à la régulation négative de MMP1, MMP2, MMP8 ou MMP9 à moins de 50 % de niveaux non traités à 100 µM dans les tissus pulmonaires affectés par une broncho-pneumopathie chronique obstructive.
Bannister Robin Mark
Chaplin Sharon Adele
Richards Andrew John Mcglashan
Arakis Ltd.
Torys Llp
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