C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C07K 14/435 (2006.01) C12N 5/10 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2289283
A method to follow the progression of metastasis of a primary tumor, which method comprises removing fresh organ tissues from a vertebrate subject which has been modified to contain tumor cells that express GFP and observing the excised tissues for the presence of fluorescence is disclosed. The fluorescence can also be monitored by observing the tissues in situ. Vertebrate subjects which contain GFP producing tumors are useful models to study the mechanism of metastasis. In addition, subjects already harboring tumors can be treated so as to modify the endogenous tumors to contain GFP. This permits clinical applications. Finally, by injecting a contrast dye into a subject harboring a GFP-labeled tumor, angiogenesis in the tumor can be observed directly.
L'invention concerne un procédé permettant de suivre la progression des métastases d'une tumeur primitive, lequel procédé consiste à prélever des tissus d'organes vivants chez un sujet vertébré qui a été modifié pour renfermer des cellules tumorales exprimant la GFP, et à détecter la présence de fluorescence dans les tissus excisés. Il est également possible de surveiller la fluorescence par une observation in situ. Les sujets vertébrés renfermant la GFP et produisant des tumeurs constituent des modèles utiles pour l'étude de la métastase. En outre, les sujets hébergeant déjà des tumeurs peuvent être traités de manière à modifier les tumeurs endogènes pour qu'elles renferment la GFP. Cette invention a des applications cliniques. Enfin, on peut observer directement l'angiogenèse en injectant un colorant de contraste dans un sujet hébergeant une tumeur marquée à la GFP.
Chishima Takashi
Tan Yuying
Anticancer Inc.
Fetherstonhaugh & Co.
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