Metering doses of sample liquids

B - Operations – Transporting – 01 – L

Patent

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B01L 3/02 (2006.01) G01N 1/10 (2006.01)

Patent

CA 2556205

A method of metering and mixing a dose of a sample liquid (17) with a diluent liquid (20) includes introducing a sample liquid (17) into a channel (33, 102) defined in a housing. The housing defines a pocket (13, 26, 28, 29, 34, 35, 38) open to the channel (33, 102) and sized to both collect a metered dose of the sample liquid (17), and to retain the collected dose by capillary force when the channel (33, 102) is emptied. The sample liquid (17) is then removed from the channel (33, 102) under conditions that enable retention of the collected, metered dose of the sample liquid (17) in the pocket (13, 26, 28, 29, 34, 35, 38). Following a cleaning step, a volume of diluent liquid (20) is introduced into the channel (33, 102) to induce diffusion and mixing of the diluent liquid (20) with the dose of sample liquid (17) to form a mixture (21).

L'invention concerne un procédé pour mesurer et mélanger une dose d'un échantillon liquide (17) avec un liquide diluant (20) comprenant l'introduction d'un échantillon liquide (17) dans un canal (33, 102) défini dans un logement. Le logement définit une poche (13, 26, 28, 29, 34, 35, 38) ouverte sur le canal (33, 102) et dimensionné de manière à collecter à la fois une dose mesurée de l'échantillon liquide (17), et à retenir la dose collectée par une force capillaire, lorsque le canal (33, 102) est vidé. L'échantillon liquide (17) est ensuite éliminé du canal (33, 102) dans des conditions qui permettent la rétention d'une dose mesurée et collectée de l'échantillon liquide (17) dans la poche (13, 26, 28, 29, 34, 35, 38). Après l'étape de nettoyage, un volume de liquide diluant (20) est introduit dans le canal (33, 102), ce qui permet d'induire la diffusion et de mélanger le liquide diluant (20) avec la dose de l'échantillon liquide (17), de manière à former un mélange (21).

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