C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/00 (2006.01) C07K 14/78 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2382774
The present invention relates to novel anti-angiogenic proteins, related to thrombospondin. More specifically, isolated nucleic acid molecules are provided encoding human METH1 and METH2. METH1 and METH2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for the prognosis of cancer and therapeutic methods for treating individuals in need of an increased amount of METH1 and METH2. Also provided are methods for inhibiting angiogenesis using METH1 or METH2.
L'invention concerne de nouvelles protéines anti-angiogéniques liées à la thrombospondine. Elle concerne notamment des molécules isolées d'acides nucléiques codant pour les polynucléotides humains METH1 et METH2. Elle concerne en outre des polypeptides METH1 et METH2 de même que des vecteurs, des cellules hôtes et des procédés recombinants pour les produire. Enfin, l'invention concerne des procédés diagnostiques pour pronostiquer le cancer et des procédés thérapeutiques pour traiter les personnes nécessitant des quantités plus importantes de METH1 et de METH2, ainsi que des procédés pour inhiber l'angiogenèse au moyen de METH1 ou de METH2.
Fornwald James A.
Hastings Gregg A.
Iruela-Arispe Luisa
Jonak Zdenka L.
Ruben Steven M.
Beth Israel Deaconess Medical Center
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
Smithkline Beecham Corporation
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