Meth1 and meth2 polynucleotides and polypeptides

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 14/78 (2006.01) C12N 1/21 (2006.01) C12N 15/63 (2006.01) C12N 15/67 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2319109

The present invention relates to novel anti-angiogenic proteins, related to thrombospondin. More specifically, isolated nucleic acid molecules are provided encoding human METH1 and METH2. METH1 and METH2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for the prognosis of cancer and therapeutic methods for treating individuals in need of an increased amount of METH1 or METH2.

La présente invention concerne de nouvelles protéines anti-angiogéniques liées à la thrombospondine. Plus spécifiquement, cette invention concerne des molécules d'acide nucléique isolées codant les METH1 et les METH 2 humaines. De même, l'invention concerne des polypeptides METH1 et METH2, des vecteurs, des cellules hôtes ainsi que des procédés de recombinaison permettant de les produire. Enfin, l'invention concerne des méthodes diagnostiques utilisées pour établir les pronostics du cancer et des méthodes thérapeutiques utilisées pour traiter des sujets ayant besoin d'une grande quantité de METH1 ou METH2.

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